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If an opioid analgesic is initiated in a patient already taking a benzodiazepine or other CNS tapentadol depressant, prescribe a lower initial dose of the opioid analgesic, and titrate based on clinical response .
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Advise tapentadol usp monograph tapentadol nederland tapentadol price australia tapentadol vs hydrocodone patients not to drive or operate heavy machinery until the effects of concomitant use of the benzodiazepine or other CNS depressants have been determined .
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Risk of Life-Threatening Respiratory Depression in tapentadol Patients with Chronic Pulmonary Disease or in Elderly, Cachectic, or Debilitated The use of NUCYNTA ER in patients with acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment is contraindicated .

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